A00-B99 C00-D48D50-D89 E00-E90 F00-F99 G00-G99 H00-H59 H60-H95 I00-I99 J00-J99 K00-K93
L00-L99 M00-M99 N00-N99 O00-O99 P00-P96 Q00-Q99 R00-R99 S00-T98 V01-Y98 Z00-Z99 U00-U99

D55-D59 Haemolytic anaemias

Chapter III

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Haemolytic anaemias

D55Anaemia due to enzyme disorders
Latin: Anaemia haemolytica enzymopathica
Excludes:drug-induced enzyme deficiency anaemia (D59.2)
D55.0Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
G6PD deficiency anaemia
D55.1Anaemia due to other disorders of glutathione metabolism
Anaemia (due to):
· enzyme deficiencies, except G6PD, related to the hexose monophosphate [HMP] shunt pathway
· haemolytic nonspherocytic (hereditary), type I
D55.2Anaemia due to disorders of glycolytic enzymes
· haemolytic nonspherocytic (hereditary), type II
· hexokinase deficiency
· pyruvate kinase [PK] deficiency
· triose-phosphate isomerase deficiency
D55.3Anaemia due to disorders of nucleotide metabolism
D55.8Other anaemias due to enzyme disorders
D55.9Anaemia due to enzyme disorder, unspecified

Latin: Thalassanaemia
D56.0Alpha thalassaemia
Excludes:hydrops fetalis due to haemolytic disease (P56.-)
D56.1Beta thalassaemia
Cooley's anaemia
Severe beta thalassaemia
· intermedia
· major
D56.2Delta-beta thalassaemia
D56.3Thalassaemia trait
D56.4Hereditary persistence of fetal haemoglobin [HPFH]
D56.8Other thalassaemias
D56.9Thalassaemia, unspecified
Mediterranean anaemia (with other haemoglobinopathy)
Thalassaemia (minor)(mixed)(with other haemoglobinopathy)

D57Sickle-cell disorders
Latin: Drepanocytosis
Excludes:other haemoglobinopathies (D58.-)
D57.0Sickle-cell anaemia with crisis
Hb-SS disease with crisis
D57.1Sickle-cell anaemia without crisis
· anaemia
· disease
· disorder
D57.2Double heterozygous sickling disorders
· Hb-SC
· Hb-SD
· Hb-SE
· sickle-cell thalassaemia
D57.3Sickle-cell trait
Hb-S trait
Heterozygous haemoglobin S
D57.8Other sickle-cell disorders

D58Other hereditary haemolytic anaemias
Latin: Anaemiae haemolyticae hereditariae aliae
D58.0Hereditary spherocytosis
Acholuric (familial) jaundice
Congenital (spherocytic) haemolytic icterus
Minkowski-Chauffard syndrome
D58.1Hereditary elliptocytosis
Elliptocytosis (congenital)
Ovalocytosis (congenital)(hereditary)
D58.2Other haemoglobinopathies
Abnormal haemoglobin NOS
Congenital Heinz body anaemia
· Hb-C
· Hb-D
· Hb-E
Haemoglobinopathy NOS
Unstable haemoglobin haemolytic disease
Excludes:familial polycythaemia (D75.0)
Hb-M disease (D74.0)
hereditary persistence of fetal haemoglobin [HPFH] (D56.4)
high-altitude polycythaemia (D75.1)
methaemoglobinaemia (D74.-)
D58.8Other specified hereditary haemolytic anaemias
D58.9Hereditary haemolytic anaemia, unspecified

D59Acquired haemolytic anaemia
Latin: Anaemia haemolytica acquisita
D59.0Drug-induced autoimmune haemolytic anaemia
Use additional external cause code (Chapter XX), if desired, to identify drug.
D59.1Other autoimmune haemolytic anaemias
Autoimmune haemolytic disease (cold type)(warm type)
Chronic cold haemagglutinin disease
Cold agglutinin:
· disease
· haemoglobinuria
Haemolytic anaemia:
· cold type (secondary)(symptomatic)
· warm type (secondary)(symptomatic)
Excludes:Evans' syndrome (D69.3)
haemolytic disease of fetus and newborn (P55.-)
paroxysmal cold haemoglobinuria (D59.6)
D59.2Drug-induced nonautoimmune haemolytic anaemia
Drug-induced enzyme deficiency anaemia
Use additional external cause code (Chapter XX), if desired, to identify drug.
D59.3Haemolytic-uraemic syndrome
D59.4Other nonautoimmune haemolytic anaemias
Haemolytic anaemia:
· mechanical
· microangiopathic
· toxic
Use additional external cause code (Chapter XX), if desired, to identify cause.
D59.5Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
Excludes:haemoglobinuria NOS (R82.3)
D59.6Haemoglobinuria due to haemolysis from other external causes
· from exertion
· march
· paroxysmal cold
Use additional external cause code (Chapter XX), if desired, to identify cause.
Excludes:haemoglobinuria NOS (R82.3)
D59.8Other acquired haemolytic anaemias
D59.9Acquired haemolytic anaemia, unspecified
Idiopathic haemolytic anaemia, chronic