F20-F29 Schizophrenia, schizotypal and delusional disorders

 
Chapter V

Mental and behavioural disorders
(F00-F99)

Schizophrenia, schizotypal and delusional disorders
(F20-F29)

This block brings together schizophrenia, as the most important member of the group, schizotypal disorder, persistent delusional disorders, and a larger group of acute and transient psychotic disorders. Schizoaffective disorders have been retained here in spite of their controversial nature.

F20		Schizophrenia Latin: Schizophrenia
		The schizophrenic disorders are characterized in general by fundamental and characteristic distortions of thinking and perception, and affects that are inappropriate or blunted. Clear consciousness and intellectual capacity are usually maintained although certain cognitive deficits may evolve in the course of time. The most important psychopathological phenomena include thought echo; thought insertion or withdrawal; thought broadcasting; delusional perception and delusions of control; influence or passivity; hallucinatory voices commenting or discussing the patient in the third person; thought disorders and negative symptoms. The course of schizophrenic disorders can be either continuous, or episodic with progressive or stable deficit, or there can be one or more episodes with complete or incomplete remission. The diagnosis of schizophrenia should not be made in the presence of extensive depressive or manic symptoms unless it is clear that schizophrenic symptoms antedate the affective disturbance. Nor should schizophrenia be diagnosed in the presence of overt brain disease or during states of drug intoxication or withdrawal. Similar disorders developing in the presence of epilepsy or other brain disease should be classified under F06.2, and those induced by psychoactive substances under F10-F19 with common fourth character .5.
		Excludes:	schizophrenia: · acute (undifferentiated) (F23.2) · cyclic (F25.2) schizophrenic reaction (F23.2) schizotypal disorder (F21)
F20.0		Paranoid schizophrenia Latin: Schizophrenia paranoides
		Paranoid schizophrenia is dominated by relatively stable, often paranoid delusions, usually accompanied by hallucinations, particularly of the auditory variety, and perceptual disturbances. Disturbances of affect, volition and speech, and catatonic symptoms, are either absent or relatively inconspicuous.
		Paraphrenic schizophrenia
		Excludes:	involutional paranoid state (F22.8) paranoia (F22.0)
F20.1		Hebephrenic schizophrenia Latin: Schizophrenia hebephrenica
		A form of schizophrenia in which affective changes are prominent, delusions and hallucinations fleeting and fragmentary, behaviour irresponsible and unpredictable, and mannerisms common. The mood is shallow and inappropriate, thought is disorganized, and speech is incoherent. There is a tendency to social isolation. Usually the prognosis is poor because of the rapid development of "negative" symptoms, particularly flattening of affect and loss of volition. Hebephrenia should normally be diagnosed only in adolescents or young adults.
		Disorganized schizophrenia Hebephrenia
F20.2		Catatonic schizophrenia Latin: Schizophrenia catatonica
		Catatonic schizophrenia is dominated by prominent psychomotor disturbances that may alternate between extremes such as hyperkinesis and stupor, or automatic obedience and negativism. Constrained attitudes and postures may be maintained for long periods. Episodes of violent excitement may be a striking feature of the condition. The catatonic phenomena may be combined with a dream-like (oneiroid) state with vivid scenic hallucinations.
		Catatonic stupor Schizophrenic: · catalepsy · catatonia · flexibilitas cerea
F20.3		Undifferentiated schizophrenia Latin: Schizophrenia non differentialis
		Psychotic conditions meeting the general diagnostic criteria for schizophrenia but not conforming to any of the subtypes in F20.0-F20.2, or exhibiting the features of more than one of them without a clear predominance of a particular set of diagnostic characteristics.
		Atypical schizophrenia
		Excludes:	acute schizophrenia-like psychotic disorder (F23.2) chronic undifferentiated schizophrenia (F20.5) post-schizophrenic depression (F20.4)
F20.4		Post-schizophrenic depression Latin: Depressio postschizophrenica
		A depressive episode, which may be prolonged, arising in the aftermath of a schizophrenic illness. Some schizophrenic symptoms, either "positive" or "negative", must still be present but they no longer dominate the clinical picture. These depressive states are associated with an increased risk of suicide. If the patient no longer has any schizophrenic symptoms, a depressive episode should be diagnosed (F32.-). If schizophrenic symptoms are still florid and prominent, the diagnosis should remain that of the appropriate schizophrenic subtype (F20.0-F20.3).
F20.5		Residual schizophrenia Latin: Schizophrenia residualis
		A chronic stage in the development of a schizophrenic illness in which there has been a clear progression from an early stage to a later stage characterized by long- term, though not necessarily irreversible, "negative" symptoms, e.g. psychomotor slowing; underactivity; blunting of affect; passivity and lack of initiative; poverty of quantity or content of speech; poor nonverbal communication by facial expression, eye contact, voice modulation and posture; poor self-care and social performance.
		Chronic undifferentiated schizophrenia Restzustand (schizophrenic) Schizophrenic residual state
F20.6		Simple schizophrenia Latin: Schizophrenia simplex
		A disorder in which there is an insidious but progressive development of oddities of conduct, inability to meet the demands of society, and decline in total performance. The characteristic negative features of residual schizophrenia (e.g. blunting of affect and loss of volition) develop without being preceded by any overt psychotic symptoms.
F20.8		Other schizophrenia Latin: Schizophrenia alia
		Cenesthopathic schizophrenia Schizophreniform: · disorder NOS · psychosis NOS
		Excludes:	brief schizophreniform disorders (F23.2)
F20.9		Schizophrenia, unspecified Latin: Schizophrenia, non specificata

F21		Schizotypal disorder Latin: Disordo schizotypicus
		A disorder characterized by eccentric behaviour and anomalies of thinking and affect which resemble those seen in schizophrenia, though no definite and characteristic schizophrenic anomalies occur at any stage. The symptoms may include a cold or inappropriate affect; anhedonia; odd or eccentric behaviour; a tendency to social withdrawal; paranoid or bizarre ideas not amounting to true delusions; obsessive ruminations; thought disorder and perceptual disturbances; occasional transient quasi-psychotic episodes with intense illusions, auditory or other hallucinations, and delusion-like ideas, usually occurring without external provocation. There is no definite onset and evolution and course are usually those of a personality disorder.
		Latent schizophrenic reaction Schizophrenia: · borderline · latent · prepsychotic · prodromal · pseudoneurotic · pseudopsychopathic Schizotypal personality disorder
		Excludes:	Asperger's syndrome (F84.5) schizoid personality disorder (F60.1)

F22		Persistent delusional disorders Latin: Psychoses paranoides persistentes
		Includes a variety of disorders in which long-standing delusions constitute the only, or the most conspicuous, clinical characteristic and which cannot be classified as organic, schizophrenic or affective. Delusional disorders that have lasted for less than a few months should be classified, at least temporarily, under F23.-.
F22.0		Delusional disorder Latin: Paranoia
		A disorder characterized by the development either of a single delusion or of a set of related delusions that are usually persistent and sometimes lifelong. The content of the delusion or delusions is very variable. Clear and persistent auditory hallucinations (voices), schizophrenic symptoms such as delusions of control and marked blunting of affect, and definite evidence of brain disease are all incompatible with this diagnosis. However, the presence of occasional or transitory auditory hallucinations, particularly in elderly patients, does not rule out this diagnosis, provided that they are not typically schizophrenic and form only a small part of the overall clinical picture.
		Paranoia Paranoid: · psychosis · state Paraphrenia (late) Sensitiver Beziehungswahn
		Excludes:	paranoid: · personality disorder (F60.0) · psychosis, psychogenic (F23.3) · reaction (F23.3) · schizophrenia (F20.0)
F22.8		Other persistent delusional disorders Latin: Psychoses paranoides persistentes aliae
		Disorders in which the delusion or delusions are accompanied by persistent hallucinatory voices or by schizophrenic symptoms that do not justify a diagnosis of schizophrenia (F20.-).
		Delusional dysmorphophobia Involutional paranoid state Paranoia querulans
F22.9		Persistent delusional disorder, unspecified Latin: Psychosis paranoides persistens, non specificata

F23		Acute and transient psychotic disorders Latin: Psychoses acutae et transitivae
		A heterogeneous group of disorders characterized by the acute onset of psychotic symptoms such as delusions, hallucinations, and perceptual disturbances, and by the severe disruption of ordinary behaviour. Acute onset is defined as a crescendo development of a clearly abnormal clinical picture in about two weeks or less. For these disorders there is no evidence of organic causation. Perplexity and puzzlement are often present but disorientation for time, place and person is not persistent or severe enough to justify a diagnosis of organically caused delirium (F05.-). Complete recovery usually occurs within a few months, often within a few weeks or even days. If the disorder persists, a change in classification will be necessary. The disorder may or may not be associated with acute stress, defined as usually stressful events preceding the onset by one to two weeks.
F23.0		Acute polymorphic psychotic disorder without symptoms of schizophrenia Latin: Psychosis polymorpha acuta sine symptomatis schizophreniae
		An acute psychotic disorder in which hallucinations, delusions or perceptual disturbances are obvious but markedly variable, changing from day to day or even from hour to hour. Emotional turmoil with intense transient feelings of happiness or ecstasy, or anxiety and irritability, is also frequently present. The polymorphism and instability are characteristic for the overall clinical picture and the psychotic features do not justify a diagnosis of schizophrenia (F20.-). These disorders often have an abrupt onset, developing rapidly within a few days, and they frequently show a rapid resolution of symptoms with no recurrence. If the symptoms persist the diagnosis should be changed to persistent delusional disorder (F22.-).
		Bouffée délirante without symptoms of schizophrenia or unspecified Cycloid psychosis without symptoms of schizophrenia or unspecified
F23.1		Acute polymorphic psychotic disorder with symptoms of schizophrenia Latin: Psychosis polymorpha acuta cum symptomatis schizophreniae
		An acute psychotic disorder in which the polymorphic and unstable clinical picture is present, as described in F23.0; despite this instability, however, some symptoms typical of schizophrenia are also in evidence for the majority of the time. If the schizophrenic symptoms persist the diagnosis should be changed to schizophrenia (F20.-).
		Bouffée délirante with symptoms of schizophrenia Cycloid psychosis with symptoms of schizophrenia
F23.2		Acute schizophrenia-like psychotic disorder Latin: Psychosis acuta schizophreniae similis
		An acute psychotic disorder in which the psychotic symptoms are comparatively stable and justify a diagnosis of schizophrenia, but have lasted for less than about one month; the polymorphic unstable features, as described in F23.0, are absent. If the schizophrenic symptoms persist the diagnosis should be changed to schizophrenia (F20.-).
		Acute (undifferentiated) schizophrenia Brief schizophreniform: · disorder · psychosis Oneirophrenia Schizophrenic reaction
		Excludes:	organic delusional [schizophrenia-like] disorder (F06.2) schizophreniform disorders NOS (F20.8)
F23.3		Other acute predominantly delusional psychotic disorders Latin: Psychoses acutae praedominanter paranoides aliae
		Acute psychotic disorders in which comparatively stable delusions or hallucinations are the main clinical features, but do not justify a diagnosis of schizophrenia (F20.-). If the delusions persist the diagnosis should be changed to persistent delusional disorder (F22.-).
		Paranoid reaction Psychogenic paranoid psychosis
F23.8		Other acute and transient psychotic disorders Latin: Psychoses acutae et transitivae aliae
		Any other specified acute psychotic disorders for which there is no evidence of organic causation and which do not justify classification to F23.0-F23.3.
F23.9		Acute and transient psychotic disorder, unspecified Latin: Psychosis acuta et transitiva, non specificata
		Brief reactive psychosis NOS Reactive psychosis

F24		Induced delusional disorder Latin: Psychosis paranoides inducta
		A delusional disorder shared by two or more people with close emotional links. Only one of the people suffers from a genuine psychotic disorder; the delusions are induced in the other(s) and usually disappear when the people are separated.
		Folie à deux Induced: · paranoid disorder · psychotic disorder

F25		Schizoaffective disorders Latin: Psychoses schizoaffectivae
		Episodic disorders in which both affective and schizophrenic symptoms are prominent but which do not justify a diagnosis of either schizophrenia or depressive or manic episodes. Other conditions in which affective symptoms are superimposed on a pre-existing schizophrenic illness, or co-exist or alternate with persistent delusional disorders of other kinds, are classified under F20-F29. Mood-incongruent psychotic symptoms in affective disorders do not justify a diagnosis of schizoaffective disorder.
F25.0		Schizoaffective disorder, manic type Latin: Psychosis schizoaffectiva, typus maniacus
		A disorder in which both schizophrenic and manic symptoms are prominent so that the episode of illness does not justify a diagnosis of either schizophrenia or a manic episode. This category should be used for both a single episode and a recurrent disorder in which the majority of episodes are schizoaffective, manic type.
		Schizoaffective psychosis, manic type Schizophreniform psychosis, manic type
F25.1		Schizoaffective disorder, depressive type Latin: Psychosis schizoaffectiva, typus depressivus
		A disorder in which both schizophrenic and depressive symptoms are prominent so that the episode of illness does not justify a diagnosis of either schizophrenia or a depressive episode. This category should be used for both a single episode and a recurrent disorder in which the majority of episodes are schizoaffective, depressive type.
		Schizoaffective psychosis, depressive type Schizophreniform psychosis, depressive type
F25.2		Schizoaffective disorder, mixed type Latin: Psychosis schizoaffectiva, typus mixtus
		Cyclic schizophrenia Mixed schizophrenic and affective psychosis
F25.8		Other schizoaffective disorders Latin: Psychoses schizoaffectivae aliae
F25.9		Schizoaffective disorder, unspecified Latin: Psychosis schizoaffectiva, non specificata
		Schizoaffective psychosis NOS

F28		Other nonorganic psychotic disorders Latin: Psychosis non organica, typus alius
		Delusional or hallucinatory disorders that do not justify a diagnosis of schizophrenia (F20.-), persistent delusional disorders (F22.-), acute and transient psychotic disorders (F23.-), psychotic types of manic episode (F30.2), or severe depressive episode (F32.3).
		Chronic hallucinatory psychosis

F29		Unspecified nonorganic psychosis Latin: Psychosis non organica, non specificata
		Psychosis NOS
		Excludes:	mental disorder NOS (F99) organic or symptomatic psychosis NOS (F09)

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F10-F19 Mental and behavioural disorders due to psychoactive substance use

 
Chapter V

Mental and behavioural disorders
(F00-F99)

Mental and behavioural disorders due to psychoactive substance use
(F10-F19)

This block contains a wide variety of disorders that differ in severity and clinical form but that are all attributable to the use of one or more psychoactive substances, which may or may not have been medically prescribed. The third character of the code identifies the substance involved, and the fourth character specifies the clinical state. The codes should be used, as required, for each substance specified, but it should be noted that not all fourth character codes are applicable to all substances.

Identification of the psychoactive substance should be based on as many sources of information as possible. These include self-report data, analysis of blood and other body fluids, characteristic physical and psychological symptoms, clinical signs and behaviour, and other evidence such as a drug being in the patient's possession or reports from informed third parties. Many drug users take more than one type of psychoactive substance. The main diagnosis should be classified, whenever possible, according to the substance or class of substances that has caused or contributed most to the presenting clinical syndrome. Other diagnoses should be coded when other psychoactive substances have been taken in intoxicating amounts (common fourth character .0) or to the extent of causing harm (common fourth character .1), dependence (common fourth character .2) or other disorders (common fourth character .3-.9).

Only in cases in which patterns of psychoactive substance-taking are chaotic and indiscriminate, or in which the contributions of different psychoactive substances are inextricably mixed, should the diagnosis of disorders resulting from multiple drug use (F19.-) be used.

The following fourth-character subdivisions are for use with categories F10-F19:
.0	Acute intoxication
	A condition that follows the administration of a psychoactive substance resulting in disturbances in level of consciousness, cognition, perception, affect or behaviour, or other psycho-physiological functions and responses. The disturbances are directly related to the acute pharmacological effects of the substance and resolve with time, with complete recovery, except where tissue damage or other complications have arisen. Complications may include trauma, inhalation of vomitus, delirium, coma, convulsions, and other medical complications. The nature of these complications depends on the pharmacological class of substance and mode of administration.
	Acute drunkenness in alcoholism "Bad trips" (drugs) Drunkenness NOS Pathological intoxication Trance and possession disorders in psychoactive substance intoxication
	Excludes:	intoxication meaning poisoning (T36-T50)
.1	Harmful use
	A pattern of psychoactive substance use that is causing damage to health. The damage may be physical (as in cases of hepatitis from the self-administration of injected psychoactive substances) or mental (e.g. episodes of depressive disorder secondary to heavy consumption of alcohol).
	Psychoactive substance abuse
.2	Dependence syndrome
	A cluster of behavioural, cognitive, and physiological phenomena that develop after repeated substance use and that typically include a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal state. The dependence syndrome may be present for a specific psychoactive substance (e.g. tobacco, alcohol, or diazepam), for a class of substances (e.g. opioid drugs), or for a wider range of pharmacologically different psychoactive substances.
	Chronic alcoholism Dipsomania Drug addiction
.3	Withdrawal state
	A group of symptoms of variable clustering and severity occurring on absolute or relative withdrawal of a psychoactive substance after persistent use of that substance. The onset and course of the withdrawal state are time-limited and are related to the type of psychoactive substance and dose being used immediately before cessation or reduction of use. The withdrawal state may be complicated by convulsions.
.4	Withdrawal state with delirium
	A condition where the withdrawal state as defined in the common fourth character .3 is complicated by delirium as defined in F05.-. Convulsions may also occur. When organic factors are also considered to play a role in the etiology, the condition should be classified to F05.8.
	Delirium tremens (alcohol-induced)
.5	Psychotic disorder
	A cluster of psychotic phenomena that occur during or following psychoactive substance use but that are not explained on the basis of acute intoxication alone and do not form part of a withdrawal state. The disorder is characterized by hallucinations (typically auditory, but often in more than one sensory modality), perceptual distortions, delusions (often of a paranoid or persecutory nature), psychomotor disturbances (excitement or stupor), and an abnormal affect, which may range from intense fear to ecstasy. The sensorium is usually clear but some degree of clouding of consciousness, though not severe confusion, may be present.
	Alcoholic: · hallucinosis · jealousy · paranoia · psychosis NOS
	Excludes:	alcohol- or other psychoactive substance-induced residual and late-onset psychotic disorder (F10-F19 with common fourth character .7)
.6	Amnesic syndrome
	A syndrome associated with chronic prominent impairment of recent and remote memory. Immediate recall is usually preserved and recent memory is characteristically more disturbed than remote memory. Disturbances of time sense and ordering of events are usually evident, as are difficulties in learning new material. Confabulation may be marked but is not invariably present. Other cognitive functions are usually relatively well preserved and amnesic defects are out of proportion to other disturbances.
	Amnestic disorder, alcohol- or drug-induced Korsakov's psychosis or syndrome, alcohol- or other psychoactive substance-induced or unspecified
	Excludes:	nonalcoholic Korsakov's psychosis or syndrome (F04)
.7	Residual and late-onset psychotic disorder
	A disorder in which alcohol- or psychoactive substance-induced changes of cognition, affect, personality, or behaviour persist beyond the period during which a direct psychoactive substance-related effect might reasonably be assumed to be operating. Onset of the disorder should be directly related to the use of the psychoactive substance. Cases in which initial onset of the state occurs later than episode(s) of such substance use should be coded here only where clear and strong evidence is available to attribute the state to the residual effect of the psychoactive substance. Flashbacks may be distinguished from psychotic state partly by their episodic nature, frequently of very short duration, and by their duplication of previous alcohol- or other psychoactive substance-related experiences.
	Alcoholic dementia NOS Chronic alcoholic brain syndrome Dementia and other milder forms of persisting impairment of cognitive functions Flashbacks Late-onset psychoactive substance-induced psychotic disorder Posthallucinogen perception disorder Residual: · affective disorder · disorder of personality and behaviour
	Excludes:	alcohol- or psychoactive substance-induced: · Korsakov's syndrome (F10-F19 with common fourth character .6) · psychotic state (F10-F19 with common fourth character .5)
.8	Other mental and behavioural disorders
.9	Unspecified mental and behavioural disorder

F10		Mental and behavioural disorders due to use of alcohol Latin: Disordines mentales et disordines morum propter usum alcholis (alcoholismus)
		[See before F10 for subdivisions]

F11		Mental and behavioural disorders due to use of opioids Latin: Disordines mentales et disordines morum propter usum opiatorum (opiatomania)
		[See before F10 for subdivisions]

F12		Mental and behavioural disorders due to use of cannabinoids Latin: Disordines mentales et disordines morum propter usum cannabinoidarum (canabinomania)
		[See before F10 for subdivisions]

F13		Mental and behavioural disorders due to use of sedatives or hypnotics Latin: Disordines mentales et disordines morum propter usum hypnoticorum sive sedativorum (hypnoticomania)
		[See before F10 for subdivisions]

F14		Mental and behavioural disorders due to use of cocaine Latin: Disordines mentales et disordines morum propter usum cocaini (cocainomania)
		[See before F10 for subdivisions]

F15		Mental and behavioural disorders due to use of other stimulants, including caffeine Latin: Disordines mentales et disordines morum propter usum stimulantium aliorum, coffeinum includens (coffeinomania)
		[See before F10 for subdivisions]

F16		Mental and behavioural disorders due to use of hallucinogens Latin: Disordines mentales et disordines morum propter usum hallucinogenium (hallucinomania)
		[See before F10 for subdivisions]

F17		Mental and behavioural disorders due to use of tobacco Latin: Disordines mentales et disordines morum propter usum tabaci (tabaccomania)
		[See before F10 for subdivisions]

F18		Mental and behavioural disorders due to use of volatile solvents Latin: Disordines mentales et disordines morum propter usum solutionum volatilium (solventomania)
		[See before F10 for subdivisions]

F19		Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances Latin: Disordines mentales et disordines morum propter usum substantiarum psychoactivarum multiplicium et aliarum
		[See before F10 for subdivisions]
		This category should be used when two or more psychoactive substances are known to be involved, but it is impossible to assess which substance is contributing most to the disorders. It should also be used when the exact identity of some or even all the psychoactive substances being used is uncertain or unknown, since many multiple drug users themselves often do not know the details of what they are taking.
		Includes:	misuse of drugs NOS

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F00-F09 Organic, including symptomatic, mental disorders

 
Chapter V

Mental and behavioural disorders
(F00-F99)

Organic, including symptomatic, mental disorders
(F00-F09)

This block comprises a range of mental disorders grouped together on the basis of their having in common a demonstrable etiology in cerebral disease, brain injury, or other insult leading to cerebral dysfunction. The dysfunction may be primary, as in diseases, injuries, and insults that affect the brain directly and selectively; or secondary, as in systemic diseases and disorders that attack the brain only as one of the multiple organs or systems of the body that are involved.

Dementia (F00-F03) is a syndrome due to disease of the brain, usually of a chronic or progressive nature, in which there is disturbance of multiple higher cortical functions, including memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement. Consciousness is not clouded. The impairments of cognitive function are commonly accompanied, and occasionally preceded, by deterioration in emotional control, social behaviour, or motivation. This syndrome occurs in Alzheimer's disease, in cerebrovascular disease, and in other conditions primarily or secondarily affecting the brain.

Use additional code, if desired, to identify the underlying disease.

F00*		Dementia in Alzheimer's disease (G30.-+) Latin: Dementia in morbo Alzheimer (G30.-)
		Alzheimer's disease is a primary degenerative cerebral disease of unknown etiology with characteristic neuropathological and neurochemical features. The disorder is usually insidious in onset and develops slowly but steadily over a period of several years.
F00.0*		Dementia in Alzheimer's disease with early onset (G30.0+)
		Dementia in Alzheimer's disease with onset before the age of 65, with a relatively rapid deteriorating course and with marked multiple disorders of the higher cortical functions.
		Alzheimer's disease, type 2 Presenile dementia, Alzheimer's type Primary degenerative dementia of the Alzheimer's type, presenile onset
F00.1*		Dementia in Alzheimer's disease with late onset (G30.1+)
		Dementia in Alzheimer's disease with onset after the age of 65, usually in the late 70s or thereafter, with a slow progression, and with memory impairment as the principal feature.
		Alzheimer's disease, type 1 Primary degenerative dementia of the Alzheimer's type, senile onset Senile dementia, Alzheimer's type
F00.2*		Dementia in Alzheimer's disease, atypical or mixed type (G30.8+)
		Atypical dementia, Alzheimer's type
F00.9*		Dementia in Alzheimer's disease, unspecified (G30.9+)

F01		Vascular dementia Latin: Dementia vascularis
		Vascular dementia is the result of infarction of the brain due to vascular disease, including hypertensive cerebrovascular disease. The infarcts are usually small but cumulative in their effect. Onset is usually in later life.
		Includes:	arteriosclerotic dementia
F01.0		Vascular dementia of acute onset
		Usually develops rapidly after a succession of strokes from cerebrovascular thrombosis, embolism or haemorrhage. In rare cases, a single large infarction may be the cause.
F01.1		Multi-infarct dementia
		Gradual in onset, following a number of transient ischaemic episodes which produce an accumulation of infarcts in the cerebral parenchyma.
		Predominantly cortical dementia
F01.2		Subcortical vascular dementia
		Includes cases with a history of hypertension and foci of ischaemic destruction in the deep white matter of the cerebral hemispheres. The cerebral cortex is usually preserved and this contrasts with the clinical picture which may closely resemble that of dementia in Alzheimer's disease.
F01.3		Mixed cortical and subcortical vascular dementia
F01.8		Other vascular dementia
F01.9		Vascular dementia, unspecified

F02*		Dementia in other diseases classified elsewhere Latin: Dementia in morbis aliis
		Cases of dementia due, or presumed to be due, to causes other than Alzheimer's disease or cerebrovascular disease. Onset may be at any time in life, though rarely in old age.
F02.0*		Dementia in Pick's disease (G31.0+)
		A progressive dementia, commencing in middle age, characterized by early, slowly progressing changes of character and social deterioration, followed by impairment of intellect, memory, and language functions, with apathy, euphoria and, occasionally, extrapyramidal phenomena.
F02.1*		Dementia in Creutzfeldt-Jakob disease (A81.0+)
		A progressive dementia with extensive neurological signs, due to specific neuropathological changes that are presumed to be caused by a transmissible agent. Onset is usually in middle or later life, but may be at any adult age. The course is subacute, leading to death within one to two years.
F02.2*		Dementia in Huntington's disease (G10+)
		A dementia occurring as part of a widespread degeneration of the brain. The disorder is transmitted by a single autosomal dominant gene. Symptoms typically emerge in the third and fourth decade. Progression is slow, leading to death usually within 10 to 15 years.
		Dementia in Huntington's chorea
F02.3*		Dementia in Parkinson's disease (G20+)
		A dementia developing in the course of established Parkinson's disease. No particular distinguishing clinical features have yet been demonstrated.
		Dementia in: · paralysis agitans · parkinsonism
F02.4*		Dementia in human immunodeficiency virus [HIV] disease (B22.0+)
		Dementia developing in the course of HIV disease, in the absence of a concurrent illness or condition other than HIV infection that could explain the clinical features.
F02.8*		Dementia in other specified diseases classified elsewhere
		Dementia in: · cerebral lipidosis (E75.-+) · epilepsy (G40.-+) · hepatolenticular degeneration (E83.0+) · hypercalcaemia (E83.5+) · hypothyroidism, acquired (E01.-+, E03.-+) · intoxications (T36-T65+) · multiple sclerosis (G35+) · neurosyphilis (A52.1+) · niacin deficiency [pellagra] (E52+) · polyarteritis nodosa (M30.0+) · systemic lupus erythematosus (M32.-+) · trypanosomiasis (B56.-+, B57.-+) · vitamin B12 deficiency (E53.8+)

F03		Unspecified dementia Latin: Dementia
		Presenile: · dementia NOS · psychosis NOS Primary degenerative dementia NOS Senile: · dementia:   · NOS   · depressed or paranoid type · psychosis NOS
		Excludes:	senile dementia with delirium or acute confusional state (F05.1) senility NOS (R54)

F04		Organic amnesic syndrome, not induced by alcohol and other psychoactive substances Latin: Syndroma amnestica organica
		A syndrome of prominent impairment of recent and remote memory while immediate recall is preserved, with reduced ability to learn new material and disorientation in time. Confabulation may be a marked feature, but perception and other cognitive functions, including the intellect, are usually intact. The prognosis depends on the course of the underlying lesion.
		Korsakov's psychosis or syndrome, nonalcoholic
		Excludes:	amnesia: · NOS (R41.3) · anterograde (R41.1) · dissociative (F44.0) · retrograde (R41.2) Korsakov's syndrome: · alcohol-induced or unspecified (F10.6) · induced by other psychoactive substances (F11-F19 with common fourth character .6)

F05		Delirium, not induced by alcohol and other psychoactive substances Latin: Delirium
		An etiologically nonspecific organic cerebral syndrome characterized by concurrent disturbances of consciousness and attention, perception, thinking, memory, psychomotor behaviour, emotion, and the sleep-wake schedule. The duration is variable and the degree of severity ranges from mild to very severe.
		Includes:	acute or subacute: · brain syndrome · confusional state (nonalcoholic) · infective psychosis · organic reaction · psycho-organic syndrome
		Excludes:	delirium tremens, alcohol-induced or unspecified (F10.4)
F05.0		Delirium not superimposed on dementia, so described
F05.1		Delirium superimposed on dementia
		Conditions meeting the above criteria but developing in the course of a dementia (F00-F03).
F05.8		Other delirium
		Delirium of mixed origin
F05.9		Delirium, unspecified

F06		Other mental disorders due to brain damage and dysfunction and to physical disease Latin: Disordines mentales propter damnum et dysfunctionem cerebri sive morbum physicum, alii
		Includes miscellaneous conditions causally related to brain disorder due to primary cerebral disease, to systemic disease affecting the brain secondarily, to exogenous toxic substances or hormones, to endocrine disorders, or to other somatic illnesses.
		Excludes:	associated with: · delirium (F05.-) · dementia as classified in F00-F03 resulting from use of alcohol and other psychoactive substances (F10-F19)
F06.0		Organic hallucinosis
		A disorder of persistent or recurrent hallucinations, usually visual or auditory, that occur in clear consciousness and may or may not be recognized by the subject as such. Delusional elaboration of the hallucinations may occur, but delusions do not dominate the clinical picture; insight may be preserved.
		Organic hallucinatory state (nonalcoholic)
		Excludes:	alcoholic hallucinosis (F10.5) schizophrenia (F20.-)
F06.1		Organic catatonic disorder
		A disorder of diminished (stupor) or increased (excitement) psychomotor activity associated with catatonic symptoms. The extremes of psychomotor disturbance may alternate.
		Excludes:	catatonic schizophrenia (F20.2) stupor: · NOS (R40.1) · dissociative (F44.2)
F06.2		Organic delusional [schizophrenia-like] disorder
		A disorder in which persistent or recurrent delusions dominate the clinical picture. The delusions may be accompanied by hallucinations. Some features suggestive of schizophrenia, such as bizarre hallucinations or thought disorder, may be present.
		Paranoid and paranoid-hallucinatory organic states Schizophrenia-like psychosis in epilepsy
		Excludes:	disorder: · acute and transient psychotic (F23.-) · persistent delusional (F22.-) · psychotic drug-induced (F11-F19 with common fourth character .5) schizophrenia (F20.-)
F06.3		Organic mood [affective] disorders
		Disorders characterized by a change in mood or affect, usually accompanied by a change in the overall level of activity, depressive, hypomanic, manic or bipolar (see F30-F38), but arising as a consequence of an organic disorder.
		Excludes:	mood disorders, nonorganic or unspecified (F30-F39)
F06.4		Organic anxiety disorder
		A disorder characterized by the essential descriptive features of a generalized anxiety disorder (F41.1), a panic disorder (F41.0), or a combination of both, but arising as a consequence of an organic disorder.
		Excludes:	anxiety disorders, nonorganic or unspecified (F41.-)
F06.5		Organic dissociative disorder
		A disorder characterized by a partial or complete loss of the normal integration between memories of the past, awareness of identity and immediate sensations, and control of bodily movements (see F44.-), but arising as a consequence of an organic disorder.
		Excludes:	dissociative [conversion] disorders, nonorganic or unspecified (F44.-)
F06.6		Organic emotionally labile [asthenic] disorder
		A disorder characterized by emotional incontinence or lability, fatigability, and a variety of unpleasant physical sensations (e.g. dizziness) and pains, but arising as a consequence of an organic disorder.
		Excludes:	somatoform disorders, nonorganic or unspecified (F45.-)
F06.7		Mild cognitive disorder
		A disorder characterized by impairment of memory, learning difficulties, and reduced ability to concentrate on a task for more than brief periods. There is often a marked feeling of mental fatigue when mental tasks are attempted, and new learning is found to be subjectively difficult even when objectively successful. None of these symptoms is so severe that a diagnosis of either dementia (F00-F03) or delirium (F05.-) can be made. This diagnosis should be made only in association with a specified physical disorder, and should not be made in the presence of any of the mental or behavioural disorders classified to F10-F99. The disorder may precede, accompany, or follow a wide variety of infections and physical disorders, both cerebral and systemic, but direct evidence of cerebral involvement is not necessarily present. It can be differentiated from postencephalitic syndrome (F07.1) and postconcussional syndrome (F07.2) by its different etiology, more restricted range of generally milder symptoms, and usually shorter duration.
F06.8		Other specified mental disorders due to brain damage and dysfunction and to physical disease
		Epileptic psychosis NOS
F06.9		Unspecified mental disorder due to brain damage and dysfunction and to physical disease
		Organic: · brain syndrome NOS · mental disorder NOS

07		Personality and behavioural disorders due to brain disease, damage and dysfunction Latin: Disordines personae et disordines morum propter morbum, damnum et dysfunctionem cerebri
		Alteration of personality and behaviour can be a residual or concomitant disorder of brain disease, damage or dysfunction.
F07.0		Organic personality disorder
		A disorder characterized by a significant alteration of the habitual patterns of behaviour displayed by the subject premorbidly, involving the expression of emotions, needs and impulses. Impairment of cognitive and thought functions, and altered sexuality may also be part of the clinical picture.
		Organic: · pseudopsychopathic personality · pseudoretarded personality Syndrome: · frontal lobe · limbic epilepsy personality · lobotomy · postleucotomy
		Excludes:	enduring personality change after: · catastrophic experience (F62.0) · psychiatric illness (F62.1) postconcussional syndrome (F07.2) postencephalitic syndrome (F07.1) specific personality disorder (F60.-)
F07.1		Postencephalitic syndrome
		Residual nonspecific and variable behavioural change following recovery from either viral or bacterial encephalitis. The principal difference between this disorder and the organic personality disorders is that it is reversible.
		Excludes:	organic personality disorder (F07.0)
F07.2		Postconcussional syndrome
		A syndrome that occurs following head trauma (usually sufficiently severe to result in loss of consciousness) and includes a number of disparate symptoms such as headache, dizziness, fatigue, irritability, difficulty in concentration and performing mental tasks, impairment of memory, insomnia, and reduced tolerance to stress, emotional excitement, or alcohol.
		Postcontusional syndrome (encephalopathy) Post-traumatic brain syndrome, nonpsychotic
F07.8		Other organic personality and behavioural disorders due to brain disease, damage and dysfunction
		Right hemispheric organic affective disorder
F07.9		Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
		Organic psychosyndrome

F09		Unspecified organic or symptomatic mental disorder Latin: Morbus mentalis organicus sive symptomaticus non specificatus
		Psychosis: · organic NOS · symptomatic NOS
		Excludes:	psychosis NOS (F29)

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E70-E90 Metabolic disorders

 
Chapter IV

Endocrine, nutritional and metabolic diseases
(E00-E90)

Metabolic disorders
(E70-E90)

Excludes:
* androgen resistance syndrome (E34.5)
* congenital adrenal hyperplasia (E25.0)
* Ehlers-Danlos syndrome (Q79.6)
* haemolytic anaemias due to enzyme disorders (D55.-)
* Marfan's syndrome (Q87.4)
* 5-alpha-reductase deficiency (E29.1)

E70		Disorders of aromatic amino-acid metabolism Latin: Disordines metabolismi aminoacidorum aromaticorum
E70.0		Classical phenylketonuria
E70.1		Other hyperphenylalaninaemias
E70.2		Disorders of tyrosine metabolism
		Alkaptonuria Hypertyrosinaemia Ochronosis Tyrosinaemia Tyrosinosis
E70.3		Albinism
		Albinism: · ocular · oculocutaneous Syndrome: · Chediak(-Steinbrinck)-Higashi · Cross · Hermansky-Pudlak
E70.8		Other disorders of aromatic amino-acid metabolism
		Disorders of: · histidine metabolism · tryptophan metabolism
E70.9		Disorder of aromatic amino-acid metabolism, unspecified

E71		Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism Latin: Disordines metabolismi aminoacidorum catenosorum et metabolismi acidorum stearicorum
E71.0		Maple-syrup-urine disease
E71.1		Other disorders of branched-chain amino-acid metabolism
		Hyperleucine-isoleucinaemia Hypervalinaemia Isovaleric acidaemia Methylmalonic acidaemia Propionic acidaemia
E71.2		Disorder of branched-chain amino-acid metabolism, unspecified
E71.3		Disorders of fatty-acid metabolism
		Adrenoleukodystrophy [Addison-Schilder] Muscle carnitine palmityltransferase deficiency
		Excludes:	Schilder's disease (G37.0)

E72		Other disorders of amino-acid metabolism Latin: Disordines metabolismi aminoacidorum, alii
		Excludes:	abnormal findings without manifest disease (R70-R89) disorders of: · aromatic amino-acid metabolism (E70.-) · branched-chain amino-acid metabolism (E71.0-E71.2) · fatty-acid metabolism (E71.3) · purine and pyrimidine metabolism (E79.-) gout (M10.-)
E72.0		Disorders of amino-acid transport
		Cystinosis Cystinuria Fanconi(-de Toni)(-Debré) syndrome Hartnup's disease Lowe's syndrome
		Excludes:	disorders of tryptophan metabolism (E70.8)
E72.1		Disorders of sulfur-bearing amino-acid metabolism
		Cystathioninuria Homocystinuria Methioninaemia Sulfite oxidase deficiency
		Excludes:	transcobalamin II deficiency (D51.2)
E72.2		Disorders of urea cycle metabolism
		Argininaemia Argininosuccinic aciduria Citrullinaemia Hyperammonaemia
		Excludes:	disorders of ornithine metabolism (E72.4)
E72.3		Disorders of lysine and hydroxylysine metabolism
		Glutaric aciduria Hydroxylysinaemia Hyperlysinaemia
		Excludes:	Refsum's disease (G60.1) Zellweger's syndrome (Q87.8)
E72.4		Disorders of ornithine metabolism
		Ornithinaemia (types I, II)
E72.5		Disorders of glycine metabolism
		Hyperhydroxyprolinaemia Hyperprolinaemia (types I, II) Non-ketotic hyperglycinaemia Sarcosinaemia
E72.8		Other specified disorders of amino-acid metabolism
		Disorders of: · Beta-amino-acid metabolism · Gamma-glutamyl cycle
E72.9		Disorder of amino-acid metabolism, unspecified

E73		Lactose intolerance Latin: Intolerantia lactosi
E73.0		Congenital lactase deficiency
E73.1		Secondary lactase deficiency
E73.8		Other lactose intolerance
E73.9		Lactose intolerance, unspecified

E74		Other disorders of carbohydrate metabolism Latin: Disordines metabolismi carbohydratorum alii
		Excludes:	increased secretion of glucagon (E16.3) diabetes mellitus (E10-E14) hypoglycaemia NOS (E16.2) mucopolysaccharidosis (E76.0-E76.3)
E74.0		Glycogen storage disease
		Cardiac glycogenosis Disease: · Andersen · Cori · Forbes · Hers · McArdle · Pompe · Tauri · von Gierke Liver phosphorylase deficiency
E74.1		Disorders of fructose metabolism
		Essential fructosuria Fructose-1,6-diphosphatase deficiency Hereditary fructose intolerance
E74.2		Disorders of galactose metabolism
		Galactokinase deficiency Galactosaemia
E74.3		Other disorders of intestinal carbohydrate absorption
		Glucose-galactose malabsorption Sucrase deficiency
		Excludes:	lactose intolerance (E73.-)
E74.4		Disorders of pyruvate metabolism and gluconeogenesis
		Deficiency of: · phosphoenolpyruvate carboxykinase · pyruvate:   · carboxylase   · dehydrogenase
		Excludes:	with anaemia (D55.-)
E74.8		Other specified disorders of carbohydrate metabolism
		Essential pentosuria Oxalosis Oxaluria Renal glycosuria
E74.9		Disorder of carbohydrate metabolism, unspecified

E75		Disorders of sphingolipid metabolism and other lipid storage disorders Latin: Disordines metabolismi sphingolipidi et depositionis lipidorum alii
		Excludes:	mucolipidosis, types I-III (E77.0-E77.1) Refsum's disease (G60.1)
E75.0		GM2 gangliosidosis
		Disease: · Sandhoff · Tay-Sachs GM2 gangliosidosis: · NOS · adult · juvenile
E75.1		Other gangliosidosis
		Gangliosidosis: · NOS · GM1 · GM3 Mucolipidosis IV
E75.2		Other sphingolipidosis
		Disease: · Fabry(-Anderson) · Gaucher · Krabbe · Niemann-Pick Farber's syndrome Metachromatic leukodystrophy Sulfatase deficiency
		Excludes:	adrenoleukodystrophy [Addison-Schilder] (E71.3)
E75.3		Sphingolipidosis, unspecified
E75.4		Neuronal ceroid lipofuscinosis
		Disease: · Batten · Bielschowsky-Jansky · Kufs · Spielmeyer-Vogt
E75.5		Other lipid storage disorders
		Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein] Wolman's disease
E75.6		Lipid storage disorder, unspecified

E76		Disorders of glycosaminoglycan metabolism Latin: Disordines metabolismi glycosaminoglycanorum
E76.0		Mucopolysaccharidosis, type I
		Syndrome: · Hurler · Hurler-Scheie · Scheie
E76.1		Mucopolysaccharidosis, type II
		Hunter's syndrome
E76.2		Other mucopolysaccharidoses
		Beta-glucuronidase deficiency Mucopolysaccharidosis, types III, IV, VI, VII Syndrome: · Maroteaux-Lamy (mild)(severe) · Morquio(-like)(classic) · Sanfilippo (type B)(type C)(type D)
E76.3		Mucopolysaccharidosis, unspecified
E76.8		Other disorders of glucosaminoglycan metabolism
E76.9		Disorder of glucosaminoglycan metabolism, unspecified

E77		Disorders of glycoprotein metabolism Latin: Disordines metabolismi glycoproteini
E77.0		Defects in post-translational modification of lysosomal enzymes
		Mucolipidosis II [I-cell disease] Mucolipidosis III [pseudo-Hurler polydystrophy]
E77.1		Defects in glycoprotein degradation
		Aspartylglucosaminuria Fucosidosis Mannosidosis Sialidosis [mucolipidosis I]
E77.8		Other disorders of glycoprotein metabolism
E77.9		Disorder of glycoprotein metabolism, unspecified

E78		Disorders of lipoprotein metabolism and other lipidaemias Latin: Disordines metabolismi lipoproteiniet lipidaemiae alii
		Excludes:	sphingolipidosis (E75.0-E75.3)
E78.0		Pure hypercholesterolaemia
		Familial hypercholesterolaemia Fredrickson's hyperlipoproteinaemia, type IIa Hyperbetalipoproteinaemia Hyperlipidaemia, group A Low-density-lipoprotein-type [LDL] hyperlipoproteinaemia
E78.1		Pure hyperglyceridaemia
		Endogenous hyperglyceridaemia Fredrickson's hyperlipoproteinaemia, type IV Hyperlipidaemia, group B Hyperprebetalipoproteinaemia Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinaemia
E78.2		Mixed hyperlipidaemia
		Broad- or floating-betalipoproteinaemia Fredrickson's hyperlipoproteinaemia, type IIb or III Hyperbetalipoproteinaemia with prebetalipoproteinaemia Hypercholesterolaemia with endogenous hyperglyceridaemia Hyperlipidaemia, group C Tubero-eruptive xanthoma Xanthoma tuberosum
		Excludes:	cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein] (E75.5)
E78.3		Hyperchylomicronaemia
		Fredrickson's hyperlipoproteinaemia, type I or V Hyperlipidaemia, group D Mixed hyperglyceridaemia
E78.4		Other hyperlipidaemia
		Familial combined hyperlipidaemia
E78.5		Hyperlipidaemia, unspecified
E78.6		Lipoprotein deficiency
		Abetalipoproteinaemia High-density lipoprotein deficiency Hypoalphalipoproteinaemia Hypobetalipoproteinaemia (familial) Lecithin cholesterol acyltransferase deficiency Tangier disease
E78.8		Other disorders of lipoprotein metabolism
E78.9		Disorder of lipoprotein metabolism, unspecified

E79		Disorders of purine and pyrimidine metabolism Latin: Disordines metabolismi purini et pyrimidini
		Excludes:	calculus of kidney (N20.0) combined immunodeficiency disorders (D81.-) gout (M10.-) orotaciduric anaemia (D53.0) xeroderma pigmentosum (Q82.1)
E79.0		Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
		Asymptomatic hyperuricaemia
E79.1		Lesch-Nyhan syndrome
E79.8		Other disorders of purine and pyrimidine metabolism
		Hereditary xanthinuria
E79.9		Disorder of purine and pyrimidine metabolism, unspecified

E80		Disorders of porphyrin and bilirubin metabolism Latin: Porphiria et disordines metabolismi bilirubini
		Includes:	defects of catalase and peroxidase
E80.0		Hereditary erythropoietic porphyria
		Congenital erythropoietic porphyria Erythropoietic protoporphyria
E80.1		Porphyria cutanea tarda
E80.2		Other porphyria
		Hereditary coproporphyria Porphyria: · NOS · acute intermittent (hepatic)
		Use additional external cause code (Chapter XX), if desired, to identify cause.
E80.3		Defects of catalase and peroxidase
		Acatalasia [Takahara]
E80.4		Gilbert's syndrome
E80.5		Crigler-Najjar syndrome
E80.6		Other disorders of bilirubin metabolism
		Dubin-Johnson syndrome Rotor's syndrome
E80.7		Disorder of bilirubin metabolism, unspecified

E83		Disorders of mineral metabolism Latin: Disordines metabolismi mineralium
		Excludes:	dietary mineral deficiency (E58-E61) parathyroid disorders (E20-E21) vitamin D deficiency (E55.-)
E83.0		Disorders of copper metabolism
		Menkes' (kinky hair)(steely hair) disease Wilson's disease
E83.1		Disorders of iron metabolism
		Haemochromatosis
		Excludes:	anaemia: · iron deficiency (D50.-) · sideroblastic (D64.0-D64.3)
E83.2		Disorders of zinc metabolism
		Acrodermatitis enteropathica
E83.3		Disorders of phosphorus metabolism
		Acid phosphatase deficiency Familial hypophosphataemia Hypophosphatasia Vitamin-D-resistant: · osteomalacia · rickets
		Excludes:	adult osteomalacia (M83.-) osteoporosis (M80-M81)
E83.4		Disorders of magnesium metabolism
		Hypermagnesaemia Hypomagnesaemia
E83.5		Disorders of calcium metabolism
		Familial hypocalciuric hypercalcaemia Idiopathic hypercalciuria
		Excludes:	chondrocalcinosis (M11.1-M11.2) hyperparathyroidism (E21.0-E21.3)
E83.8		Other disorders of mineral metabolism
E83.9		Disorder of mineral metabolism, unspecified

E84		Cystic fibrosis Latin: Fibrosis cystica
		Includes:	mucoviscidosis
E84.0		Cystic fibrosis with pulmonary manifestations
E84.1		Cystic fibrosis with intestinal manifestations
		Meconium ileus+ (P75*)
		Excludes:	meconium obstruction in cases where cystic fibrosis is known not to be present (P76.0)
E84.8		Cystic fibrosis with other manifestations
		Cystic fibrosis with combined manifestations
E84.9		Cystic fibrosis, unspecified

E85		Amyloidosis Latin: Amyloidosis
		Excludes:	Alzheimer's disease (G30.-)
E85.0		Non-neuropathic heredofamilial amyloidosis
		Familial Mediterranean fever Hereditary amyloid nephropathy
E85.1		Neuropathic heredofamilial amyloidosis
		Amyloid polyneuropathy (Portuguese)
E85.2		Heredofamilial amyloidosis, unspecified
E85.3		Secondary systemic amyloidosis
		Haemodialysis-associated amyloidosis
E85.4		Organ-limited amyloidosis
		Localized amyloidosis
E85.8		Other amyloidosis
E85.9		Amyloidosis, unspecified

E86		Volume depletion Latin: Dehydratio et hypovolaemia
		Dehydration Depletion of volume of plasma or extracellular fluid Hypovolaemia
		Excludes:	dehydration of newborn (P74.1) hypovolaemic shock: · NOS (R57.1) · postoperative(T81.1) · traumatic (T79.4)

E87		Other disorders of fluid, electrolyte and acid-base balance Latin: Disordines fluidi, electrolyti et aequilibrii acidobasis alii
E87.0		Hyperosmolality and hypernatraemia
		Sodium [Na] excess Sodium [Na] overload
E87.1		Hypo-osmolality and hyponatraemia
		Sodium [Na] deficiency
		Excludes:	Syndrome of inappropriate secretion of antidiuretic hormone (E22.2)
E87.2		Acidosis
		Acidosis: · NOS · lactic · metabolic · respiratory
		Excludes:	diabetic acidosis (E10-E14 with common fourth character .1)
E87.3		Alkalosis
		Alkalosis: · NOS · metabolic · respiratory
E87.4		Mixed disorder of acid-base balance
E87.5		Hyperkalaemia
		Potassium [K] excess Potassium [K] overload
E87.6		Hypokalaemia
		Potassium [K] deficiency
E87.7		Fluid overload
		Excludes:	oedema (R60.-)
E87.8		Other disorders of electrolyte and fluid balance, not elsewhere classified
		Electrolyte imbalance NOS Hyperchloraemia Hypochloraemia

E88		Other metabolic disorders Latin: Disordines metabolismi alii
		Use additional external cause code (Chapter XX), if desired, to identify drug, if drug-induced.
		Excludes:	histiocytosis X (chronic) (D76.0)
E88.0		Disorders of plasma-protein metabolism, not elsewhere classified
		Alpha-1-antitrypsin deficiency Bisalbuminaemia
		Excludes:	disorder of lipoprotein metabolism (E78.-) monoclonal gammopathy (D47.2) polyclonal hypergammaglobulinaemia (D89.0) Waldenström's macroglobulinaemia (C88.0)
E88.1		Lipodystrophy, not elsewhere classified
		Lipodystrophy NOS
		Excludes:	Whipple's disease (K90.8)
E88.2		Lipomatosis, not elsewhere classified
		Lipomatosis: · NOS · dolorosa [Dercum]
E88.8		Other specified metabolic disorders
		Launois-Bensaude adenolipomatosis Trimethylaminuria
E88.9		Metabolic disorder, unspecified

E89		Postprocedural endocrine and metabolic disorders, not elsewhere classified Latin: Disordines endocrini et disordines metabolici postprocedurales
E89.0		Postprocedural hypothyroidism
		Postirradiation hypothyroidism Postsurgical hypothyroidism
E89.1		Postprocedural hypoinsulinaemia
		Postpancreatectomy hyperglycaemia Postsurgical hypoinsulinaemia
E89.2		Postprocedural hypoparathyroidism
		Parathyroprival tetany
E89.3		Postprocedural hypopituitarism
		Postirradiation hypopituitarism
E89.4		Postprocedural ovarian failure
E89.5		Postprocedural testicular hypofunction
E89.6		Postprocedural adrenocortical(-medullary) hypofunction
E89.8		Other postprocedural endocrine and metabolic disorders
E89.9		Postprocedural endocrine and metabolic disorder, unspecified

E90*		Nutritional and metabolic disorders in diseases classified elsewhere Latin: Disordines nutritionis et disordines metabolismi in morbis aliis

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